An isothermal reverse transcriptase helicase-dependent amplification (RT-HDA) assay intended for the qualitative detection of nucleic acid from SARS-CoV-2 in nasopharyngeal (NP) and nasal (NS) swab specimens from individuals suspected of having COVID-19 by their health-care provider. Molecular identification of SARS-CoV-2 occurs by the use of targeting highly conserved regions of the SARS-CoV-2 virus nonstructural polyprotein (pp1ab). The assay consists of 2 major steps: (1) specimen preparation, and (2) amplification and detection of target sequences specific to SARS-CoV-2 using isothermal reverse transcriptase helicase-dependent amplification (RT-HDA) in the presence of target-specific fluorescence probes which is performed in the Solana instrument. Results are displayed on the touchscreen, can be saved to the instrument, printed, and are capable of being sent to the LIS and exported through one of Solana’s 5 USB ports. Solana SARS-CoV-2 Assay is also supported by the power of Virena. Moderately complex.